Natural ginger is up to 10,000 times more effective than chemotherapy drugs at treating cancer, study shows
Ginger naturally contains a compound that is up to 10,000 times more effective than chemotherapy drugs at killing the cancer stem cells that make malignant tumors so dangerous, according to a study published in the journal PLoS.
The chemical, known as 6-shogaol, is produced when ginger roots are dried or cooked. The researchers found that 6-shogaol is active against cancer stem cells at concentrations that are harmless to healthy cells. This is dramatically different from conventional chemotherapy, which has serious side effects largely because it kills healthy as well as cancerous cells.
Cells responsible for 90 percent of cancer death?
Like other stem cells, cancer stem cells possess the ability to differentiate into various different cell types. In the case of cancer, stem cells differentiate into the various malignant cells that make up a tumor colony. Although they make up less than 1 percent of the cells in any given tumor, stem cells are impervious to nearly all known or experimental chemotherapy agents. These cells are also able to replicate indefinitely, and they are capable of splitting off from their originating colony to start new tumors elsewhere. They are key players in the process of metastasis, which is responsible for 90 percent of cancer-related deaths.
The persistence of cancer stem cells also explains why cancers can recur even after seemingly successful tumor eradication via chemotherapy, radiation or surgery.
"Cancer stem cells pose serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse," the researchers wrote. "To add into the misery, very few chemotherapeutic compounds show promise to kill these cells."
Kills cancer cells on many fronts
The researchers found that 6-shogaol targets breast cancer stem cells along several different pathways, including reducing the expression of surface markers, altering the cell cycle to increase the rate of cell death, inhibiting tumor formation, directly inducing programmed cell death, and flat-out poisoning cancer stem cells (cytotoxicity).
The researchers then compared the cytotoxicity of 6-shogaol against human breast cancer stem cells with that of the widely used chemotherapy drug taxol. They found that while taxol did show cytotoxicity in a one-dimensional laboratory model of cancer ("monolayer"), it showed almost no effect in the three-dimensional ("spheroid") model that is now believed to be a more accurate model of real-world cancer tumors. 6-shogaol, however, was effective in both the monolayer and spheroid models.
The researchers then increased the taxol concentration by 10,000 times, but it still showed no effectiveness in spheroid model.
"[T]axol, even though was highly active in monolayer cells, did not show activity against the spheroids even at 10,000 fold higher concentration compared to 6-shogaol," the researchers wrote.
The promise of food-based cures
The fact that 6-shogaol naturally occurs in a widely consumed human food is promising for its safety profile, the researchers noted.
"Dietary compounds are welcome options for human diseases due to their time-tested acceptability by human bodies," they wrote.
Another food-based chemical that has shown promise against cancer stem cells is phenethyl isothiocyanate (PEITC). This chemical is produced from the reaction of a compound and an enzyme that occur in cruciferous vegetables, such as broccoli and cabbage. This reaction actually takes place simply when the vegetables are chewed, which means that eating cruciferous vegetables causes the human body to be exposed to PEITC.
According to a May 2015 press release by researchers from the South Dakota State University Department of Health and Nutritional Sciences, PEITC has been successful at killing cervical cancer stem cells. The concentrations used in the study are actually achievable simply from a diet rich in cruciferous vegetables, the researchers said. The vegetables highest in PEITC potential are watercress and land cress.
This research suggests that PEITC, and possibly even a diet rich in cruciferous vegetables, could assist in the prevention of or recovery from cancer.
I have two cases at the moment that are most topical as there is in the news this week an article where senior medical people ask for the capping of costs for IVF treatment. http://www.bbc.com/news/health-34658354. Whatever one thinks, and Nature appears to be ignored in this discussion, the creation of a child other than by natural means is clearly a huge lot of trouble not to mention the cost to the State. So, is there possibly a way round this, and avoiding noxious chemicals? There just might be, for some.
I have a friend, who does not believe in natural remedies, who has produced twin boys after three attempts at IVF. I also have a client who was troubled with serious menstrual pains. She had uterine fibroids that she asked me if I could help with. I immediately suggested Home Cures Serrapeptase Strong ™ and Home Cures Curcumin99™. She has recently emailed me to say she is so delighted, she is pregnant and deliriously happy after trying for years to have a baby.
The first lady did not take any Serrapeptase or Curcumin, despite entreaties; the second has had a good result. However, one thing is clear from this; that infertility is not always insurmountable. Yes it is on the increase, lifestyle taking a massive part of the blame. No, it is not always the end of the story before the IVF route. And natural remedies are known to be better than any chemicals. Here are extracts from Lady N° 2’s emails of her route to happiness.
In November 2014 I stopped « The Pill » because of the risks of the possible cancerous and other unwanted side effects…. I rather think that it is possibly the pill that was the cause of my pains and almost certainly my fibroids.
In July 2015 I saw a Consultant for my painful periods and it was found that I had small , 8mm, fibroids, considered too small to do anything about with conventional medication. As I said I had stopped contraception in November 2014, … and then, thanks to an article on the internet, in September this year I contacted you. Then in October I got pregnant. I am so happy !
John Osborne, a Naturopath of many years experience, works with the leading authorities in the world on the natural ways to cure serious illness. John is readily contactable via his web site, www.homecures.co.uk where he is happy to advise on all forms of natural treatment for bodily sickness. (John is not a doctor so is not able to offer any diagnosis.)
McDonald's is trying everything to keep customers flocking through their doors, but the brand, the product and the strategy continue to falter. Many McDonald's franchisees say the brand is suffering from a "deep depression" leading to the "final days" of the once popular business model.
Nomura analyst Mark Kalinowski sent out surveys to 29 McDonald's franchisees in the United States, spanning 226 restaurants in total. Many of the owners' responses clearly show that the McDonald's fast food empire is entering its final days of dominance.
"We are in the throes of a deep depression, and nothing is changing," said one franchisee. "Probably 30% of operators are insolvent."
Franchisees speak out against McDonald's core problems
Over a dozen franchisees lashed out at corporate management, calling CEO Steve Easterbrook's new marketing initiatives a distraction from the core issues that plague the McDonald's business model. New initiatives, like the all-day breakfast and the placement of new digital ordering kiosks, do not address the real problems at McDonald's.
One franchisee wrote, "The lack of consistent leadership from Oak Brook is frightening, we continue to jump from one failed initiative to another."
The franchisees admit what the core problems are; it's the quality of the food and the customer service. The all-day breakfast plan has only made the menu and kitchen operations more complicated. Initiatives like these don't address the food's lack of quality or the type of ingredients customers are rejecting.
Consumers are growing wary of products like the 19-ingredient French fries and hamburger meat that likely come from cows raised in confined animal feeding operations (CAFOs). Likewise, consumers are increasingly rejecting genetically modified ingredients and flocking to new business models as a result. After announcing that they will no longer be using genetically modified ingredients, up and coming fast food company Chipotle saw a meteoric rise in revenue, while expanding their business model in 2015. Chipotle, which has consistently been setting higher standards, has already opened 48 stores this year and plans to introduce at least 190 more, according to CEO Steve Ells.
McDonald's business model dying out
One franchisee responded to the survey by detailing how the McDonald's model is quickly becoming a thing of the past. "The CEO is sowing the seeds of our demise. We are a quick-serve fast-food restaurant, not a fast casual like Five Guys or Chipotle. The system may be facing its final days," he wrote.
Another franchisee said that the corporate office is not listening to franchisees and is instead telling them to just "get out of the system" and quit.
McDonald's boasts of over 14,000 restaurants in the US; however, the fast food juggernaut has seen seven straight quarters of same store sales declines. McDonald's has been making changes to see what could work. Some of their recent changes are a step in the right direction, like their announcement to remove antibiotics from their chicken sources.
It it may be too little, too late, however, for a brand that is dying off in the hearts of consumers who now turn to other fast food chains for higher standards and better service.